Hypermethylation of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia
نویسندگان
چکیده
منابع مشابه
DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma
The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair such as hMLH1, MGMT, and GSTP1, and a gastric cancer-specifically methylated DNA fragment, MINT 25 in gastric cancer cases and control groups. The study population consisted of 100 gastric cancer patients (50...
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The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
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ژورنال
عنوان ژورنال: World Journal of Gastrointestinal Oncology
سال: 2009
ISSN: 1948-5204
DOI: 10.4251/wjgo.v1.i1.41